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2-Chloroquinoline-4-carbonyl chloride
- Name 2-Chloroquinoline-4-carbonyl chloride
- CAS 2388-32-1
- Purity 99%
Product Details
Buy high quality and low price 2-Chloroquinoline-4-carbonyl chloride 2388-32-1 now
- Molecular Formula: C10H5Cl2NO
- Molecular Weight: 226.062
- Vapor Pressure: 8.17E-05mmHg at 25°C
- Melting Point: 89 °C(Solv: benzene (71-43-2))
- Refractive Index: 1.66
- Boiling Point: 341.2 °C at 760 mmHg
- PKA: -2.82±0.50(Predicted)
- Flash Point: 160.2 °C
- PSA： 29.96000
- Density: 1.457 g/cm3
- LogP: 3.26720
2-Chloroquinoline-4-carbonyl chloride(Cas 2388-32-1) Usage
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General Description |
2-Chloroquinoline-4-carbonyl chloride is a chemical compound that belongs to the class of organochlorine compounds. These are organic compounds containing a chlorine atom. In particular, this compound contains a quinoline, a nitrogen-containing aromatic compound with a two-ring structure. It is a relatively less researched chemical but is known to be used as a reagent in the synthesis of various complex molecules used in the pharmaceutical and chemical industries. Its properties, such as its physical state, boiling point, melting point, and specific gravity, may vary depending on its purity and other conditional factors. As with many chemicals, it should be handled with care to avoid any harm or reaction. |
InChI:InChI=1/C10H5Cl2NO/c11-9-5-7(10(12)14)6-3-1-2-4-8(6)13-9/h1-5H
2388-32-1 Relevant articles
Identification of dibucaine derivatives as novel potent enterovirus 2C helicase inhibitors: In vitro, in vivo, and combination therapy study
Chen, Yinuo,Feng, Leilei,Jin, Mengyu,Lan, Ke,Shu, Ting,Tang, Qi,Wu, Shuwen,Xu, Zhichao,Zhang, Qiuhan,Zhou, Hai-Bing
, (2020)
Enterovirus A71 (EV-A71) is a human path...
Synthesis and antiinflammatory and analgesic activity of 2-substituted cinchoninic acid amides
Pavlova,Mikhalev,Kon'shin,Zaks,Vasilyuk,Vakhrin
, p. 419 - 420 (1999)
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Method for preparing N-(2-(diethyl)aminoethyl)-2-chloro-4-quinolinecarboxamide
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Paragraph 0024-0029, (2019/03/08)
The invention discloses a method for pre...
Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity
Li, Wenlong,Xu, Feijie,Shuai, Wen,Sun, Honghao,Yao, Hong,Ma, Cong,Xu, Shengtao,Yao, Hequan,Zhu, Zheying,Yang, Dong-Hua,Chen, Zhe-Sheng,Xu, Jinyi
, p. 993 - 1013 (2019/01/11)
A series of novel quinoline-chalcone der...
Quinoline formamide compound and preparation method thereof and application of anti-enterovirus type 71
-
Paragraph 0027-0030, (2020/01/03)
The invention discloses a quinoline form...
2388-32-1 Process route
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5467-57-2
2-chloroquinoline-4-carboxylic acid
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2388-32-1
2-chloroquinoline-4-carbonyl chloride
| Conditions | Yield |
|---|---|
|
With
thionyl chloride;
for 1h;
Heating;
|
|
|
With
thionyl chloride;
for 1h;
Heating;
|
|
|
With
thionyl chloride; N,N-dimethyl-formamide;
In
tetrahydrofuran;
at 0 - 60 ℃;
for 2h;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
|
|
|
With
thionyl chloride;
Reflux;
|
|
|
With
thionyl chloride;
for 2h;
Inert atmosphere;
Reflux;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 0 - 20 ℃;
for 1h;
|
|
|
With
thionyl chloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 55 ℃;
for 4h;
|
|
|
With
thionyl chloride;
In
dichloromethane;
at 55 ℃;
for 4h;
|
-
-
15733-89-8,84906-81-0
2-hydroxyquinoline-4-carboxylic acid
-
-
2388-32-1
2-chloroquinoline-4-carbonyl chloride
| Conditions | Yield |
|---|---|
|
With
phosphorus pentachloride; chlorine; 1,2-dichloro-ethane;
|
|
|
With
thionyl chloride; benzene;
|
|
|
With
phosphorus pentachloride;
|
|
|
With
phosphorus pentachloride; trichlorophosphate;
for 18h;
Heating / reflux;
|
|
|
With
trichlorophosphate;
at 100 ℃;
for 1h;
|
|
|
With
phosphorus pentachloride; trichlorophosphate;
|
|
|
With
thionyl chloride;
In
1,2-dichloro-ethane;
at 80 ℃;
for 2h;
|
|
|
With
thionyl chloride; N,N-dimethyl-formamide;
In
dichloromethane;
for 3h;
Inert atmosphere;
Resolution of racemate;
|
|
|
With
thionyl chloride;
In
N,N-dimethyl-formamide;
for 5h;
Reflux;
|
2388-32-1 Upstream products
-
15733-89-8
2-hydroxyquinoline-4-carboxylic acid
-
5467-57-2
2-chloroquinoline-4-carboxylic acid
-
15733-89-8
2-quinolone-4-carboxylic acid
-
91-56-5
indole-2,3-dione
2388-32-1 Downstream products
-
135323-96-5
(2-chloroquinolin-4-yl)(piperidin-1-yl)methanone
-
135323-95-4
(2-chloro-quinolin-4-yl)-(morpholin-4-yl)-methanone
-
861020-37-3
1-(2-chloro-quinoline-4-carbonyl)-4-phenyl-piperazine
-
107779-36-2
2-(n-butyloxy)-4-(n-butyloxycarbonyl)-quinoline
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