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2,6-bis[(2-methylphenyl)methylene]cyclohexan-1-one

  • Name 2,6-bis[(2-methylphenyl)methylene]cyclohexan-1-one
  • CAS 85391-70-4
  • Purity 99%
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Product Details

Chemical plants supply high-quality 2,6-bis[(2-methylphenyl)methylene]cyclohexan-1-one 85391-70-4 in bulk

  • Molecular Formula: C22H22 O
  • Molecular Weight: 302.416
  • Vapor Pressure: 1.39E-09mmHg at 25°C 
  • Melting Point: 139 °C 
  • Boiling Point: 485.6°C at 760 mmHg 
  • Flash Point: 212.8°C 
  • PSA： 17.07000 
  • Density: 1.115g/cm3 
  • LogP: 5.52340 

2,6-bis[(2-methylphenyl)methylene]cyclohexan-1-one(Cas 85391-70-4) Usage

Appearance

Colorless to pale yellow solid

Molecular weight

242.36 g/mol

Physical properties

Musky, animal-like odor

Usage

Commonly used in perfumes and fragrances, flavoring industry, and as a potential pharmaceutical agent

Benefits

Enhances and extends longevity of fragrances, imparts musky note to food and beverages, has potential anti-inflammatory and anti-cancer properties

Environmental concerns

Being phased out in many consumer products due to environmental concerns

Alternatives

More sustainable and eco-friendly alternatives are being sought after for use in consumer products.

General Description

2,6-bis[(2-methylphenyl)methylene]cyclohexan-1-one, also known as muscone, is a synthetic musk compound commonly used in the production of perfumes and fragrances. It is a cyclic ketone with a musky, animal-like odor and is valued for its ability to enhance and extend the longevity of fragrances. Muscone is also used in the flavoring industry to impart a musky note to food and beverage products. In addition, it has been studied for its potential pharmaceutical applications, including its ability to act as an anti-inflammatory and anti-cancer agent. However, due to environmental concerns, muscone is being phased out of use in many consumer products in favor of more sustainable and eco-friendly alternatives.

InChI:InChI=1/C22H22O/c1-16-8-3-5-10-18(16)14-20-12-7-13-21(22(20)23)15-19-11-6-4-9-17(19)2/h3-6,8-11,14-15H,7,12-13H2,1-2H3

85391-70-4 Relevant articles

Ag/P-Stereogenic Phosphine-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions: A Method to Optically Active Pyrrolidines

Zhi, Mengna,Gan, Zhenjie,Ma, Rong,Cui, Hao,Li, Er-Qing,Duan, Zheng,Mathey, Fran?ois

supporting information, (2019/05/07)

A Ag/P-stereogenic phosphine-complex-cat...

Chiral Cyclohexyl-Fused Spirobiindanes: Practical Synthesis, Ligand Development, and Asymmetric Catalysis

Zheng, Zhiyao,Cao, Yuxi,Chong, Qinglei,Han, Zhaobin,Ding, Jiaming,Luo, Chenguang,Wang, Zheng,Zhu, Dongsheng,Zhou, Qi-Lin,Ding, Kuiling

supporting information, p. 10374 - 10381 (2018/08/03)

1,1′-Spirobiindane has been one type of ...

Inhibitor of CBP histone acetyltransferase downregulates p53 activation and facilitates methylation at lysine 27 on histone H3

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85391-70-4 Process route

cyclohexanone
108-94-1,11119-77-0,9003-41-2,9075-99-4

cyclohexanone

2-methylphenyl aldehyde
529-20-4

2-methylphenyl aldehyde

(2E,6E)-2,6-bis(2-methylbenzylidene)cyclohexanone
85391-70-4,1174731-16-8

(2E,6E)-2,6-bis(2-methylbenzylidene)cyclohexanone

Conditions
Conditions Yield
With sodium hydroxide; In ethanol; water; at 20 ℃; for 10h;
92%
With montmorillonite K-10; In methanol; at 100 ℃; Microwave irradiation;
8%
With sodium hydroxide; In ethanol; water; at 20 ℃; for 2h; Inert atmosphere;
cyclohexanone
108-94-1,11119-77-0,9003-41-2,9075-99-4

cyclohexanone

2-methylphenyl aldehyde
529-20-4

2-methylphenyl aldehyde

(E)-2-(2-methylbenzylidene)cyclohexanone
58635-27-1

(E)-2-(2-methylbenzylidene)cyclohexanone

(2E,6E)-2,6-bis(2-methylbenzylidene)cyclohexanone
85391-70-4,1174731-16-8

(2E,6E)-2,6-bis(2-methylbenzylidene)cyclohexanone

Conditions
Conditions Yield
With potassium hydroxide;

85391-70-4 Upstream products

  • 108-94-1
    108-94-1

    cyclohexanone

  • 529-20-4
    529-20-4

    2-methylphenyl aldehyde

85391-70-4 Downstream products

  • 1313510-87-0
    1313510-87-0

    4-(2-methylphenyl)-8-[(E)-(2-methylphenyl)-methylidene]-3-(3-phenyl-1,2,4-oxadiazol-5-yl)-5,6,7,8-tetrahydro-4H-chromen-2-ylamine

  • 1313510-65-4
    1313510-65-4

    2-amino-4-(2-methylphenyl)-8-[(E)-(2-methylphenyl)-methylidene]-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

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